Senior Scientist, Antibody Discovery, Engineering, and Production

Company: Takeda Pharmaceutical
Location: Clifton
Posted on: November 12, 2021

Job Description:

By clicking the -Apply- button, I understand that my employment application process with Takeda will commence and that the information I provide in my application will be processed in line with Takeda's and . I further attest that all information I submit in my employment application is true to the best of my knowledge.Job DescriptionAre you looking for a patient-focused, innovation-driven company that will inspire you and empower you to shine? Join us as a Senior Scientist, Antibody Discovery, Engineering, and Production, Global Biologics in our Cambridge, MA office.At Takeda, we are transforming the pharmaceutical industry through our R&D-driven market leadership and being a values-led company. To do this, we empower our people to realize their potential through life-changing work. Certified as a Global Top Employer, we offer stimulating careers, encourage innovation, and strive for excellence in everything we do. We foster an inclusive, collaborative workplace, in which our global teams are united by an unwavering commitment to deliver Better Health and a Brighter Future to people around the world.Here, you will be a vital contributor to our inspiring, bold mission.POSITION OBJECTIVES:Takeda is committed to the long-term strategy and vision to translate science into life-changing medicines that make critical differences for our patients around the world. The Global Biologics team within R&D consists of approx. 85 scientists across two US sites (Cambridge MA and San Diego) and aims to discover novel therapeutic large molecule biologics serving our four main therapeutic areas Oncology, Gastroenterology, Neuroscience and Rare Disease.We are excited to pursue the search for a Senior Scientist to join our Biotherapeutic Engineering team, a group within Takeda's Global Biologics Department. You will join a team of motivated and enthusiastic scientists, bringing strong experience in antibody/biologic discovery and engineering and a new diversity of experience to our knowledge base, as we continue to build on our existing discovery platforms. You will have industrial experience in the field of current state-of-the-art antibody discovery and engineering using platforms such as phage or yeast display (including FACS analysis and sorting), as well as expert-level general molecular biology skills, applied towards library design, construction, affinity-maturation, humanization and other engineering aspects. Experience with multi-specific antibody modalities and cell therapy is an excellent advantage. Familiarity with repertoire analysis using both NGS and Sanger sequencing methods is also preferred. -This position will also support high throughput production and purification of antibodies or other biologics from yeast.- Familiarity with protein production and purification from yeast is beneficial but not critical as this aspect of the role will involve appropriate training on our high throughput yeast production platform.POSITION ACCOUNTABILITIES:

• Thoughtfully design and implement successful discovery campaigns using in vivo and in vitro platforms
• Handle and manipulate display libraries from discovery through optimization to isolate large diversity of relevant biologics for programs
• Harvest diverse repertoires from immunized animals to display libraries for further manipulation.
• Design maturation libraries for display platforms (affinity/ potency/ stability) leveraging datasets, experience and software to improve lead candidates.
• Manage sequence analysis through state-of-the-art tools for deep understanding and performance of campaigns.
• Conduct small and medium scale expression of antibodies/biologics in yeast. This includes dedicated workflows for multiple 96 and/or 24 well productions.
• Purify and quantify proteins using high throughput platforms, followed by basic characterization of purified proteins using standard techniques.
• Work with data analysis tools to ensure thorough evaluation of datasets and information based next step decision making, in addition to summarize and present findings to smaller and larger teams.
• High level of diligence in all data tracking, uploading and recording using data management systems within the department.
• Oversee and manage workflows with thirds parties and/or CROs where appropriate.
• Serve as an effective lead of discovery programs, collaborate and interact with team members and other internal groups for high efficiency and transparency to enable progression of molecules.
• Demonstrate pro-activity through identifying areas to improve efficiency, perform technology development to bring new innovation to the team, where appropriate.
• Independently design, develop and execute research assignments and contribute to multiple projects, in parallel.
• Perform as a solid team member, working together with the smaller and larger groups in a team orientated, data sharing manner.
• Work efficiently with a sense of urgency to meet program and team needs.
• Contribution to the preparation of patents, documentation for IND, and publications.EDUCATION, BEHAVIORAL COMPETENCIES AND SKILLS:
  • PhD (5+ years' experience), or MS (10+ years' experience) or BS (12+years' experience) in Immunology/Cell Biology/Biochemistry or related fields.
  • Minimum of 2 years of experience in antibody discovery in a biotech/pharma setting.
  • Excellent knowledge of antibody discovery and engineering with demonstrated experience of antibody discovery and engineering using display platform (phage or yeast)
  • Excellent familiarity with antibody repertoire analysis- NGS data handling and analysis from either in vivo -or in vitro sources.
  • Experiences with multi-specific antibody modalities and cell therapy is highly preferred.
  • Experience with standard molecular and cell biology techniques.
  • Ability to develops and oversees novel scientific projects and will manage the work of others directly or in a matrixed structure
  • Ability to independently manages workload and expectations, provides information to group to influence direction.
  • Effective resource and time management is essential.
  • Effective oral and written communication as well as strong interpersonal skills required.
  • Hard working, enthusiastic, self-motivated, team oriented with a strong collaborative spirit.WHAT TAKEDA CAN OFFER YOU:
    • 401(k) with company match and Annual Retirement Contribution Plan
    • Tuition reimbursement Company match of charitable contributions
    • Health & Wellness programs including onsite flu shots and health screenings
    • Generous time off for vacation and the option to purchase additional vacation days
    • Community Outreach ProgramsEmpowering Our People to ShineDiscover more at takedajobs.comNo Phone Calls or Recruiters Please.This job posting excludes CO applicants.Effective November 1, 2021, absent an approved religious or medical reason, all US office-based and lab-based Takeda employees who work fully on-site or in a hybrid model (as determined by Takeda) must be fully vaccinated to work at a Takeda site or to engage with Takeda colleagues or anyone else on behalf of Takeda. As of the same date, absent an approved religious or medical reason, US field-based employees, employees must be fully vaccinated in order to continue in their current roles. US employees who work at a Takeda manufacturing facility, and those who work at a BioLife center or BioLife lab, may be subject to different guidelines. Candidates are encouraged to speak with their recruiter to seek further information on the applicable guidelines for the Business Unit/Function for which they have applied.#LI-SGMEEO StatementTakeda is proud in its commitment to creating a diverse workforce and providing equal employment opportunities to all employees and applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, gender expression, parental status, national origin, age, disability, citizenship status, genetic information or characteristics, marital status, status as a Vietnam era veteran, special disabled veteran, or other protected veteran in accordance with applicable federal, state and local laws, and any other characteristic protected by law.LocationsBoston, MAWorker TypeEmployeeWorker Sub-TypeRegularTime TypeFull time

Keywords: Takeda Pharmaceutical, Clifton , Senior Scientist, Antibody Discovery, Engineering, and Production, Professions , Clifton, New Jersey